Natural polysaccharides protect against diet-induced obesity by improving lipid metabolism and regulating the immune system

C Tang, Y Wang, D Chen, M Zhang, J Xu, C Xu… - Food Research …, 2023 - Elsevier
Unhealthy dietary patterns-induced obesity and obesity-related complications pose a great
threat to human health all over the world. Accumulating evidence suggests that the …

Protective and ameliorating effects of probiotics against diet-induced obesity: A review

C Tang, L Kong, M Shan, Z Lu, Y Lu - Food Research International, 2021 - Elsevier
Diet-induced obesity is one of the major public health concerns all over the world, and
obesity also contributes to the development of other chronic diseases such as non-alcoholic …

Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms

Q Wu, Q Wang, J Fu, R Ren - Food & function, 2019 - pubs.rsc.org
With great changes in people's lifestyles, the incidence of hyperlipidaemia has dramatically
increased in recent years. Numerous studies have demonstrated that natural …

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice

Y Chen, L Chen, X Wu, Y Zhao, Y Wang… - Nature …, 2023 - nature.com
The early phase lipid accumulation is essential for liver regeneration. However, whether this
acute lipid accumulation can serve as signals to direct liver regeneration rather than simply …

Cholesterol Induces Nrf‐2‐ and HIF‐1α‐Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and …

Y Kaminsky-Kolesnikov, E Rauchbach… - Oxidative Medicine …, 2020 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) is currently one of the most common liver diseases
worldwide. The toxic effects of lipids and bile acids contribute to NASH. The regenerative …

Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division

MJ Caldez, M Bjorklund, P Kaldis - Hepatology international, 2020 - Springer
Cell division is essential for organismal growth and tissue homeostasis. It is exceptionally
significant in tissues chronically exposed to intrinsic and external damage, like the liver. After …

Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish

Q Yu, J Huo, Y Zhang, K Liu, Y Cai, T Xiang, Z Jiang… - Chemosphere, 2020 - Elsevier
Tamoxifen is a clinical drug for estrogen receptor (ER)-positive breast cancer. Recently, it
has been detected in aquatic environment. The residual drugs will produce certain …

Lipidomics Indicates the Hepatotoxicity Effects of EtOAc Extract of Rhizoma Paridis

C Li, M Wang, T Fu, Z Li, Y Chen, T He… - Frontiers in …, 2022 - frontiersin.org
Rhizoma Paridis is a traditional Chinese medicine commonly used in the clinical treatment
of gynecological diseases. Previous studies have shown that aqueous extracts of Rhizoma …

Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration

M Kong, W Dong, H Xu, Z Fan, X Miao… - Frontiers in Cell and …, 2021 - frontiersin.org
Liver regeneration is a key compensatory process in response to liver injury serving to
contain damages and to rescue liver functions. Hepatocytes, having temporarily exited the …

Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway

Y Cheng, X Xiang, C Liu, T Cai, T Li… - Journal of Agricultural …, 2022 - ACS Publications
Alcoholic liver disease (ALD) is caused by alcohol abuse and can progress to hepatitis,
cirrhosis, and even hepatocellular carcinoma. Previous studies suggested that Lactobacillus …