Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

The immune system is vital for safeguarding the human body against infections and
inflammatory diseases. The role of diet and meal patterns in modulating immune function is …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

Alzheimer's disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the
brain, a process normally facilitated by apolipoprotein E (apoE). ApoE expression is …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Thousands of organic micropollutants and their transformation products occur in water.
Although often present at low concentrations, individual compounds contribute to mixture …

Rationale: The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. The
4 microRNAs representing the miR-143 and miR-145 stem loops are genomically clustered …

The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We
generated a comprehensive transcriptional profile of the separate stages of spontaneous …

This chapter presents an overview of the current status of studies on the structural and
molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1–3), their …