When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Upon solid organ transplantation and during cancer immunotherapy, cellular stress
responses result in the release of damage-associated molecular patterns (DAMPs). The …

Patients with chronic kidney disease (CKD) are at a high risk for cardiovascular disease
(CVD), and approximately half of all deaths among patients with CKD are a direct result of …

Abstract The Injury Hypothesis, first published in 1994 and modified several times between
1996 and 2002, holds that the reactive oxygen species-mediated reperfusion injury to …

Maintaining organ viability after donation until transplantation is critically important for
optimal graft function and survival. To date, static cold storage is the most widely used form …

Solid organ transplantation was one of the greatest medical advances during the past few
decades. Organ preservation solutions have been applied to diminish ischemic/hypoxic …

1 H-NMR–based metabolic signatures of mild and severe ischemia/reperfusion injury in rat
kidney transplants. Background Severe ischemia/reperfusion (IR) injury is a risk factor for …

Hypothermic perfusion preservation (HPP) was an integral step in the development of early
clinical transplantation programmes, and considerable progress was made in understanding …

The final decision to accept an organ for transplantation remains a subjective one. With
“poor organ quality” commonly cited as a major reason for kidney discard, accurate …

Caring for a brain dead potential organ donor requires a shift in critical care from the
extensive treatment of increased intracranial pressure towards strategies to maintain donor …