R Wang, B Li, SM Lam, G Shui - Journal of genetics and genomics, 2020 - Elsevier
Mass spectrometry (MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …
VR Varma, AM Oommen, S Varma, R Casanova… - PLoS …, 2018 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are …
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new …
SG Snowden, AA Ebshiana, A Hye, Y An… - PLoS …, 2017 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …
In advanced age, some individuals maintain a stable cognitive trajectory while others experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …
The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In …
Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic …
Introduction The aim of this study was to (1) replicate previous associations between six blood lipids and Alzheimer's disease (AD)(Proitsi et al 2015) and (2) identify novel …