Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Lonidamine (LND) was initially introduced as an antispermatogenic agent. It was later found
to have anticancer activity sensitizing tumors to chemo-, radio-, and photodynamic-therapy …

Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKTmTOR)
signaling pathway is an important in the aetiology of pancreatic cancer (PC) and is …

Mitochondrial membrane permeabilization is a critical event in the process leading to
physiologic or chemotherapy-induced apoptosis (programmed cell death). This …

Apoptosis or programmed cell death is a process with typical morphological characteristics
including plasma membrane blebbing, cell shrinkage, chromatin condensation and …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …