Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been
used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and …

Highlights•This Clinical Practice Guideline provides key recommendations on the
management of bone sarcomas.•Recommendations have been agreed following a …

PURPOSE The primary aim of this phase III randomized trial was to test whether the addition
of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed …

Background Talazoparib combined with irinotecan and temozolomide demonstrated efficacy
in a murine Ewing sarcoma model. Based on these data, we conducted a phase I trial of …

Simple Summary Ewing sarcoma is a highly aggressive malignancy affecting primarily
children and adolescents. It is the second most common bone sarcoma among children …

Bone sarcoma are infrequent diseases, representing< 0.2% of all adult neoplasms. A
multidisciplinary management within reference centers for sarcoma, with discussion of the …

Abstract The eighth Paediatric Strategy Forum focused on multi-targeted kinase inhibitors
(mTKIs) in osteosarcoma and Ewing sarcoma. The development of curative, innovative …

Background In preclinical Ewing sarcoma (ES) models, poly (adenosine diphosphate
ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with …

Background: Topoisomerase I is an enzyme that plays a crucial part in DNA replication and
transcription by the relaxation of supercoiled double-stranded DNA. Topoisomerase I …