Gene therapy using CRISPR Cas9 technique is rapidly gaining popularity among the
scientific community primarily because of its versatility, cost-effectiveness, and high efficacy …

CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the
most fascinating tools of the current era in molecular biotechnology. With the ease that they …

Background The lactate receptor GPR81 contributes to cancer development through unclear
mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo …

Protocadherin-7 (Pcdh7) is a member of the non-clustered protocadherin δ1 subgroup of the
cadherin superfamily. Pcdh7 has been revealed to control osteoclast differentiation by …

There are health benefits from consuming cruciferous vegetables that release indole-3-
carbinol (I3C), but the in vivo transformation of I3C-related indoles remains …

Summary Loss of Protocadherin 9 (PCDH9) is associated with the metastasis and the
prognosis of gastric cancer patients, while the molecular mechanism of PCDH9-impaired …

Oncogenic RAS variants lead to constitutive overactivation and increased signal
transduction into downstream pathways. They are found as somatic driver events in various …

Background Lung cancer is one of the most malignant tumors. However, neither the
pathogenesis of lung cancer nor the prognosis markers are completely clear. The purpose of …

Lung malignant tumors are a type of cancer with high incidence and mortality rates
worldwide. Non-small cell lung cancer (NSCLC) accounts for over 80% of all lung malignant …

Background Lung adenocarcinoma (LUAD) is the leading histological subtype of lung
cancer worldwide, causing high mortality each year. The tumor immune cell infiltration (ICI) …