Down syndrome is the most common chromosomal abnormality among live-born infants.
Through full or partial trisomy of chromosome 21, Down syndrome is associated with …

Evidence in mouse models for Down syndrome (DS) and human fetuses with DS clearly
shows severe neurogenesis impairment in various telencephalic regions, suggesting that …

Sex chromosome disorders severely compromise gametogenesis in both males and
females. In oogenesis, the presence of an additional Y chromosome or the loss of an X …

Down syndrome (DS) is a genetic pathology characterized by intellectual disability and brain
hypotrophy. Widespread neurogenesis impairment characterizes the fetal and neonatal DS …

Abstract Trisomic Ts65Dn mice show direct parallels with many phenotypes of Down
syndrome (DS), including effects on the structure of cerebellum and hippocampus. A small …

Quantitative differences in gene expression emerge as a significant source of variation in
natural populations, representing an important substrate for evolution and accounting for a …

Dysregulation of brain insulin signaling with reduced downstream neuronal survival and
plasticity mechanisms are fundamental abnormalities observed in Alzheimer disease (AD) …

Cognitive disability is an unavoidable feature of Down syndrome (DS), a genetic disorder
due to the triplication of human chromosome 21. DS is associated with alterations of …

Down syndrome (DS) is a developmental disorder associated with mental retardation (MR)
and early onset Alzheimer's disease (AD). These CNS phenotypes are attributed to ongoing …

Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Reduced neurogenesis and impaired neuron maturation are …