The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone …

Although potent combination antiretroviral therapy can effectively block viral replication in
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …

The Mediator complex directs signals from DNA-binding transcription factors to RNA
polymerase II (Pol II). Despite this pivotal position, mechanistic understanding of Mediator in …

Nearly half of the human genome consists of endogenous retroelements (EREs) and their
genetic remnants, a small fraction of which carry the potential to propagate in the host …

Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

Several transcriptional and epigenetic regulators have been functionally linked to the control
of viral and cellular gene expression programs. One such regulator is Krüppel-associated …

CDK7 phosphorylates the RNA polymerase II (pol II) C-terminal domain CTD and activates
the P-TEFb-associated kinase CDK9, but its regulatory roles remain obscure. Here, using …

Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal
pausing and its release. Previously, we showed that Pol II–associated factor 1 (PAF1) …