The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

This review summarizes the newly discovered molecular mechanism of secretin‐stimulated
urine HCO3–excretion and the role of cystic fibrosis transmembrane conductance regulator …

Spotted sea bass (Lateolabrax maculatus), possessing a superior adaptation ability to a
wide range of salinities, is a valuable candidate to develop saline-alkaline tolerant fish …

The urinary potassium (K+) excretion machinery is upregulated with increasing dietary K+,
but the role of accompanying dietary anions remains inadequately characterized. Poorly …

Background: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly,
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …

Objective Metabolic acidosis and the uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate
(PCS), are associated with increased risks of kidney disease progression, muscle …

Background Chronic kidney disease (CKD) leads to an accumulation of waste products and
causes adverse cardiometabolic effects. Objectives We investigated the health effects of the …

Loss-of-function mutations in the human potassium chloride cotransporter-3 (KCC3) cause a
hereditary motor sensory neuropathy associated with agenesis of the corpus callosum …

Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …

The kidney plays a key role in the correction of systemic acid-base imbalances. Central for
this regulation are the intercalated cells in the distal nephron, which secrete acid or base …