Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

The development of type 1 and type 2 diabetes mellitus has a substantial negative impact on
morbidity and mortality and is responsible for substantial individual and socioeconomic …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated
with dysregulation and overactivation of the complement alternative pathway. Typically …

Thrombomodulin (TM), which is predominantly expressed on the endothelium, plays an
important role in maintaining vascular homeostasis by regulating the coagulation system …

A role of coagulation proteases in kidney disease beyond their function in normal
haemostasis and thrombosis has long been suspected, and studies performed in the past 15 …

The thrombomodulin (TM)/activated protein C (APC) system plays an important role in
maintaining the homeostasis of thrombosis and hemostasis and maintaining vascular …