Carob extract induces spermatogenesis in an infertile mouse model via upregulation of Prm1, Plzf, Bcl-6b, Dazl, Ngn3, Stra8, and Smc1b

Z Ghorbaninejad, A Eghbali, M Ghorbaninejad… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Ethnopharmacological studies for drug discovery from
natural compounds play an important role for developing current therapeutical platforms …

Busulfan-mediated oxidative stress and genotoxicity decrease in sperm of Satureja Khuzestanica essential oil-administered mice

P Nasimi, MR Tabandeh, S Roohi - Systems Biology in …, 2018 - Taylor & Francis
Here, we studied the protective effects of Satureja Khuzestanica essential oil (SKEO) as a
potent anti-oxidant, against damage caused by chemotherapy with busulfan in testis and …

Busulfan induces oxidative stress-and Bcl-2 family gene-related apoptosis in epididymal sperm and testis of adult male mice

P Nasimi, MR Tabandeh, A Vahdati… - Physiology and …, 2015 - ppj.phypha.ir
Introduction: Busulfan as a chemotherapeutic agent causes testicular germinal epithelium
depletion and cytotoxicity in germ cells. The aim of this study was to assess antioxidant …

Effects of melatonin on both testicular regeneration and recovery of spermatogenesis in busulfan-treated rats

E Taslidere, M Esrefoglu, OE Tok… - Brazilian Journal of …, 2022 - SciELO Brasil
Testicular damage is one of the most hazardous effects of chemotherapy as it is frequently
associated with oligozoospermia and azoospermia. This study aimed at evaluating the …

[HTML][HTML] Effect of Satureja khuzestanica essential oil against fertility disorders induced by busulfan in female mice

A Ahmadi, SB Chafjiri… - Veterinary Research Forum, 2017 - ncbi.nlm.nih.gov
Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction.
Satureja khuzestanica has antioxidant effects. The aim of this study was to examine whether …

The protective effects of melatonin on the histological changes of testis in busulfan-treated adult mice

F Mohamadghasemi, M Faghani… - … of Reproduction & …, 2010 - search.proquest.com
Introduction: Antineoplastic chemotherapy is usually accompanied by fertility impairment
and the aim of this study was to investigate the possible protective effects of melatonin, a …

Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model

H Mobarak, R Rahbarghazi, M Nouri… - BMC Pharmacology and …, 2022 - Springer
Background Administration of antineoplastic drugs may cause azoospermia driving to
subfertility. Production of animal azoospermia models is essential for evaluating new …

Effects of Letrozole and Crocin Combination on Sperm Motility and Biochemical Markers in Azoospermia: Insights from Gene Expression Analysis

SN Zaeem, MH Nasrabadi, M Salehipour, S Ehtsham - 2024 - researchsquare.com
Azoospermia, characterized by the absence of sperm in ejaculation, is a severe male
infertility condition resulting from defects in spermatogenesis or the testicular duct system …

[HTML][HTML] Study of side effects of busulfan on testis tissue and epididymal sperm of adult mice following treatment with clinical dose

S KH - Cell and Tissue Journal, 2016 - jct.araku.ac.ir
Aim: The aim of this study was to assess side effects of clinical dose of busulfan on testis and
epididymal sperm of adult male mouse. Material and Methods: Male adult NMRI mice (25-35 …

Resveratrol and L-carnitine affects protamine gene expression and sperm parameters in an azoospermic rat model

H Hafezi, A Vahdati, M Frozanfar… - medical journal of …, 2021 - mjms.mums.ac.ir
The anticancer agent, busulfan, has been reported to adversely affect the male reproductive
system such as damaging the sperm parameters. It was shown that L-carnitine and …