Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

Arcobacter has emerged as an important food-borne zoonotic pathogen, causing sometimes
serious infections in humans and animals. Newer species of Arcobacter are being …

BACKGROUND & AIMS: Matrix metalloproteases (MMPs) mediate pathogenesis of chronic
intestinal inflammation. We characterized the role of the gelatinase (GelE), a …

Background & Aims: There is mounting evidence that matrix metalloproteinases are the
predominant proteinases expressed in the gut mucosa during active inflammatory bowel …

Abstract Background and Aims Matrix metalloproteinases [MMPs] play an important role in
extracellular matrix regulation during cell growth and wound healing. Increased expression …

Background: Fistulae are a troublesome complication of Crohn's disease but little is known
of the final effector molecules responsible for matrix degradation. Although matrix …

Background: T cell-mediated immunity plays a central part in the pathogenesis of tissue
damage in inflammatory bowel disease (IBD). The mechanism by which T cells mediate …

Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal
tract, encompassing two main disorders: Crohn's disease (CD) and ulcerative colitis (UC). In …

Intestinal fibrosis and strictures frequently occur in Crohn's disease but not ulcerative colitis.
We have recently shown that, compared to myofibroblasts obtained from normal and …

Background and Aims Celiac disease (CD) is a chronic inflammatory disorder of the small
intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically …