Osthole: An overview of its sources, biological activities, and modification development
M Sun, M Sun, J Zhang - Medicinal Chemistry Research, 2021 - Springer
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants
such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and …
such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and …
Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson
Cnidium monnieri (L.) Cusson (CMC) is a traditional Chinese herbal medicine that has been
widely grown and used in Asia. It is also known as “She chuang zi” in China (Chinese …
widely grown and used in Asia. It is also known as “She chuang zi” in China (Chinese …
The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB …
H Fan, Z Gao, K Ji, X Li, J Wu, Y Liu, X Wang, H Liang… - Phytomedicine, 2019 - Elsevier
Background Ulcerative colitis (UC) is a chronic inflammatory condition of the intestines and
is difficult to cure once diagnosed. The efficacy of the current clinical treatment for UC is …
is difficult to cure once diagnosed. The efficacy of the current clinical treatment for UC is …
Serum cytokine levels in children with spectrum autism disorder: Differences in pro-and anti-inflammatory balance
NK Kordulewska, E Kostyra, K Piskorz-Ogórek… - Journal of …, 2019 - Elsevier
Abstract Background Autism Spectrum Disorders (ASDs) is a developmental and
neurological disorder that affects all aspects of social communication, with limited and …
neurological disorder that affects all aspects of social communication, with limited and …
New insights into the binding mechanism between osthole and β-lactoglobulin: Spectroscopic, chemometrics and docking studies
R Wang, Y Liu, X Hu, J Pan, D Gong… - Food Research …, 2019 - Elsevier
Osthole, a type of coumarin derivative, owns many biological functions, but the poor water
solubility and low bioavailability limit its usage in food and pharmaceutical fields. β …
solubility and low bioavailability limit its usage in food and pharmaceutical fields. β …
Modulatory effects of osthole on lipopolysaccharides-induced inflammation in Caco-2 cell monolayer and co-cultures with THP-1 and THP-1-derived macrophages
NK Kordulewska, J Topa, M Tańska, A Cieślińska… - Nutrients, 2020 - mdpi.com
Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they
may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide …
may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide …
Osthole attenuates ovalbumin‑induced lung inflammation via the inhibition of IL‑33/ST2 signaling in asthmatic mice
Q Yang, L Kong, W Huang… - International …, 2020 - spandidos-publications.com
Asthma is a common chronic inflammatory airway disease. Recent studies have reported
that interleukin (IL)‑33 is a potential link between the airway epithelium and Th2‑type …
that interleukin (IL)‑33 is a potential link between the airway epithelium and Th2‑type …
A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole
NK Kordulewska, E Kostyra, B Chwała… - International …, 2019 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by
Diagnosis and Statistic Manual 5 (DSM-5) as persistent social interaction and …
Diagnosis and Statistic Manual 5 (DSM-5) as persistent social interaction and …
Osthole inhibits expression of genes associated with toll-like receptor 2 signaling pathway in an organotypic 3D skin model of human epidermis with atopic dermatitis
NK Kordulewska, J Topa, R Stryiński, B Jarmołowska - Cells, 2021 - mdpi.com
The Toll-like receptor (TLR) family signature has been linked to the etiopathology of atopic
dermatitis (AD), a chronic inflammatory skin disease associated with skin barrier dysfunction …
dermatitis (AD), a chronic inflammatory skin disease associated with skin barrier dysfunction …
Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES …
NK Kordulewska, E Kostyra, A Cieślińska… - Immunobiology, 2017 - Elsevier
Introduction Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is
assumed as a natural antihistamine alternative. This paper compares results of histamine …
assumed as a natural antihistamine alternative. This paper compares results of histamine …