Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …

Unresectable hepatocellular carcinoma (uHCC) is one of the most lethal and prevalent
cancers worldwide, and current systemic therapeutic options for uHCC are limited …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

Purpose Transarterial chemoembolization (TACE) is the standard of care for patients with
intermediate-stage hepatocellular carcinoma (HCC). Lenvatinib, a multikinase inhibitor, and …

Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …

Liver fibrosis results from chronic liver injury triggered by factors such as viral infection,
excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver …