Targeting memory T cell metabolism to improve immunity
Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …
and facilitating the development of persistent immunologic memory toward the vaccine …
Epigenetic control of CD8+ T cell differentiation
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
L Codarri Deak, V Nicolini, M Hashimoto, M Karagianni… - Nature, 2022 - nature.com
Expansion and differentiation of antigen-experienced PD-1+ TCF-1+ stem-like CD8+ T cells
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
CD8+ T cells are essential components of the immune response against viral infections and
tumours, and are capable of eliminating infected and cancerous cells. However, when the …
tumours, and are capable of eliminating infected and cancerous cells. However, when the …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells
A Bachem, C Makhlouf, KJ Binger, DP de Souza, D Tull… - Immunity, 2019 - cell.com
Interactions with the microbiota influence many aspects of immunity, including immune cell
development, differentiation, and function. Here, we examined the impact of the microbiota …
development, differentiation, and function. Here, we examined the impact of the microbiota …
Checkpoint blockade immunotherapy induces dynamic changes in PD-1− CD8+ tumor-infiltrating T cells
An improved understanding of the anti-tumor CD8+ T cell response after checkpoint
blockade would enable more informed and effective therapeutic strategies. Here we …
blockade would enable more informed and effective therapeutic strategies. Here we …
Proliferating transitory T cells with an effector-like transcriptional signature emerge from PD-1+ stem-like CD8+ T cells during chronic infection
T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent
studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1+ …
studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1+ …
Origin and differentiation of human memory CD8 T cells after vaccination
RS Akondy, M Fitch, S Edupuganti, S Yang, HT Kissick… - Nature, 2017 - nature.com
The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity …
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity …