BRAF Alteration in Central and Peripheral Nervous System Tumors

K Srinivasa, KA Cross, S Dahiya - Frontiers in Oncology, 2020 - frontiersin.org
BRAF (alternately referred to as v-raf murine sarcoma viral oncogene homolog B1) is a proto-
oncogene involved in the mitogen-activated protein kinase (MAPK) pathway. BRAF …

Pleomorphic Xanthoastrocytoma: a single institution retrospective analysis and a review of the literature

B Detti, S Scoccianti, V Maragna, S Lucidi… - La radiologia …, 2022 - Springer
Background Pleomorphic xanthoastrocytoma (PXA) is a rare low-grade brain tumor. To date,
limited studies have analyzed factors affecting survival outcomes and defined the …

Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types

A Reinhardt, K Pfister, D Schrimpf… - Neuropathology and …, 2022 - Wiley Online Library
Aims Anaplastic ganglioglioma is a rare tumour, and diagnosis has been based on
histological criteria. The 5th edition of the World Health Organization Classification of …

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

L Gabler, D Lötsch, D Kirchhofer… - Acta neuropathologica …, 2019 - Springer
The BRAF gene and the TERT promoter are among the most frequently altered genomic loci
in low-grade (LGG) and high-grade-glioma (HGG), respectively. The coexistence of BRAF …

Differences in treatment patterns and overall survival between grade II and anaplastic pleomorphic xanthoastrocytomas

A Rodrigues, H Bhambhvani, ZA Medress… - Journal of Neuro …, 2021 - Springer
Abstract Introduction Pleomorphic xanthoastrocytomas (PXAs) are classified as a grade II
neoplasm, typically occur in children, and have favorable prognoses. However, their …

Exploring prognostic factors and treatment strategies for long-term survival in pleomorphic xanthoastrocytoma patients

C Lee, Y Byeon, GJ Kim, J Jeon, CK Hong, JH Kim… - Scientific Reports, 2024 - nature.com
Pleomorphic xanthoastrocytomas (PXA) are rare, accounting for< 1% of all astrocytomas.
Literature on the clinical course and treatment outcomes of PXAs is limited. The study aimed …

Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging

J Yan, C Guo, H Zheng, Y Li, M Duan, C Zhang, L Cui… - BMC cancer, 2024 - Springer
Objectives Seeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic
xanthoastrocytomas (PXAs) is essential for their prognoses and therapeutic use of BRAF …

Predictors of outcome in pleomorphic xanthoastrocytoma

A Dono, V Lopez-Rivera, A Chandra… - Neuro-Oncology …, 2021 - academic.oup.com
Background Pleomorphic xanthoastrocytomas (PXA) are circumscribed gliomas that
typically have a favorable prognosis. Limited studies have revealed factors affecting survival …

Pathologic and molecular aspects of anaplasia in circumscribed gliomas and glioneuronal tumors

E Pujadas, L Chen, FJ Rodriguez - Brain tumor pathology, 2019 - Springer
Many breakthroughs have been made in the past decade regarding our knowledge of the
biological basis of the diffuse gliomas, the most common primary central nervous system …

Clinical, morphological, and molecular study on grade 2 and 3 pleomorphic xanthoastrocytoma

H Zhang, XJ Ma, XP Xiang, QY Wang, JL Tang, XY Yu… - Current …, 2023 - mdpi.com
Purpose: Pleomorphic xanthoastrocytoma (PXA) is an uncommon astrocytoma that tends to
occur in children and young adults and has a relatively favorable prognosis. The 2021 WHO …