The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Genome and exome sequencing yield extensive catalogues of human genetic variation.
However, pinpointing the few phenotypically causal variants among the many variants …

Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

Computational efforts to identify functional elements within genomes leverage comparative
sequence information by looking for regions that exhibit evidence of selective constraint …

Methods for detecting nucleotide substitution rates that are faster or slower than expected
under neutral drift are widely used to identify candidate functional elements in genomic …

Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …

Regulatory T (Treg) cells, whose differentiation and function are controlled by X
chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and …

A major yet unresolved quest in decoding the human genome is the identification of the
regulatory sequences that control the spatial and temporal expression of genes. Distant …

The functional consequences of genetic variation in mammalian regulatory elements are
poorly understood. We report the in vivo dissection of three mammalian enhancers at single …

We have developed a comprehensive gene orientated phylogenetic resource,
EnsemblCompara GeneTrees, based on a computational pipeline to handle clustering …