Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …

Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction,
and its evaluation would be of considerable importance to stratify CV risk of many diseases …

Studies over the last decade have provided exciting new insights into potential mechanisms
underlying the pathogenesis of preeclampsia. The initiating event in preeclampsia is …

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

Objective: Mitochondrial production of oxidants contributes to a variety of pathological
conditions including the vascular complications of diabetes, neurodegenerative diseases …

BACKGROUND Pre-eclampsia, small-for-gestational-age infants, preterm birth and
recurrent miscarriage complicate a significant number of pregnancies. The vascular …

Genetic studies in mice and humans have revealed the pivotal role of transforming growth
factor-β (TGF-β) signaling during angiogenesis. Mice deficient for various TGF-β signaling …

Preeclampsia is a hypertensive, multisystem disorder of pregnancy whose etiology remains
unknown. Although management is evidence‐based, preventative measures/screening …

Endoglin (CD105) is an accessory protein of the transforming growth factor-β receptor
system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated …