Close international collaboration between pediatric oncologists has led to marked
improvements in the cure of patients, seen as a long-term overall survival rate of about 80 …

Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …

The clinical course of neuroblastoma is more heterogeneous than any other malignant
disease. Most low-risk patients experience regression after limited or even no …

Purpose Metastatic response to induction therapy for high-risk neuroblastoma is a
prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma …

Purpose To assess objective response rate (ORR) after two cycles of temozolomide in
combination with topotecan (TOTEM) in children with refractory or relapsed neuroblastoma …

Aim To assess objective response after two cycles of temozolomide and topotecan (TOTEM)
in children with refractory or relapsed miscellaneous extracranial solid and central nervous …

Background: The purpose of this meta-analysis was to evaluate the therapeutic efficacy of
topoisomerase inhibitors in the treatment of high-grade gliomas (HGGs). Materials and …

Abstract In the European Union, the pediatric medicines regulation in 2007 modified
significantly the access to new agents in pediatric oncology. Early oncology trials are still …

Neuroblastoma is a complex disease with many contradictions and challenges. It is, by and
large, a cancer of babies and preschool children, but it does occur, albeit increasingly rarely …

Background: Temozolomide (TMZ) oral suspension (Ped-TMZ, KIZFIZO®) is being
developed for the treatment of relapsed or refractory neuroblastoma, a rare cancer affecting …