Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …

Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Abstract Changes in promoter structure and occupation have been shown to modify the
splicing pattern of several genes, evidencing a coupling between transcription and …

Gene expression in eukaryotes requires several multi-component cellular machines. Each
machine carries out a separate step in the gene expression pathway, which includes …

Alternative splicing of human cystic fibrosis transmembrane conductance regulator (CFTR)
exon 9 is regulated by a combination of cis‐acting elements distributed through the exon …