Recent advances in microfluidic techniques for single-cell biophysical characterization

Y Zheng, J Nguyen, Y Wei, Y Sun - Lab on a Chip, 2013 - pubs.rsc.org
Biophysical (mechanical and electrical) properties of living cells have been proven to play
important roles in the regulation of various biological activities at the molecular and cellular …

Single cell electrical characterization techniques

MA Mansor, MR Ahmad - International journal of molecular sciences, 2015 - mdpi.com
Electrical properties of living cells have been proven to play significant roles in
understanding of various biological activities including disease progression both at the …

[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

C Denning, V Borgdorff, J Crutchley, KSA Firth… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

[HTML][HTML] Single cell studies of mouse embryonic stem cell (mESC) differentiation by electrical impedance measurements in a microfluidic device

Y Zhou, S Basu, E Laue, AA Seshia - Biosensors and Bioelectronics, 2016 - Elsevier
Biological populations of cells show considerable cell-to-cell variability. Study of single cells
and analysis of cell heterogeneity are considered to be critical in understanding biological …

Single-cell printer: automated, on demand, and label free

A Gross, J Schöndube, S Niekrawitz… - Journal of …, 2013 - journals.sagepub.com
Within the past years, single-cell analysis has developed into a key topic in cell biology to
study cellular functions that are not accessible by investigation of larger cell populations …

Development of microfluidic impedance cytometry enabling the quantification of specific membrane capacitance and cytoplasm conductivity from 100,000 single cells

Y Zhao, K Wang, D Chen, B Fan, Y Xu, Y Ye… - Biosensors and …, 2018 - Elsevier
This paper presents a new microfluidic impedance cytometry with crossing constriction
microchannels, enabling the characterization of cellular electrical markers (eg, specific …

Heart-on-a-chip based on stem cell biology

E Jastrzebska, E Tomecka, I Jesion - Biosensors and Bioelectronics, 2016 - Elsevier
Heart diseases are one of the main causes of death around the world. The great challenge
for scientists is to develop new therapeutic methods for these types of ailments. Stem cells …

A high-throughput flow cytometry-on-a-CMOS platform for single-cell dielectric spectroscopy at microwave frequencies

JC Chien, A Ameri, EC Yeh, AN Killilea, M Anwar… - Lab on a Chip, 2018 - pubs.rsc.org
This work presents a microfluidics-integrated label-free flow cytometry-on-a-CMOS platform
for the characterization of the cytoplasm dielectric properties at microwave frequencies …

[HTML][HTML] Current strategies and challenges for purification of cardiomyocytes derived from human pluripotent stem cells

K Ban, S Bae, Y Yoon - Theranostics, 2017 - ncbi.nlm.nih.gov
Cardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) are considered a
most promising option for cell-based cardiac repair. Hence, various protocols have been …

Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays

DM Titmarsh, NR Glass, RJ Mills, A Hidalgo… - Scientific reports, 2016 - nature.com
Inducing cardiomyocyte proliferation in post-mitotic adult heart tissue is attracting significant
attention as a therapeutic strategy to regenerate the heart after injury. Model animal screens …