Cholinesterase inhibitors as Alzheimer's therapeutics

K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …

Clinical trials and late‐stage drug development for A lzheimer's disease: an appraisal from 1984 to 2014

LS Schneider, F Mangialasche… - Journal of internal …, 2014 - Wiley Online Library
The modern era of drug development for A lzheimer's disease began with the proposal of
the cholinergic hypothesis of memory impairment and the 1984 research criteria for A …

Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement

GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

The cholinergic hypothesis of Alzheimer's disease: a review of progress

PT Francis, AM Palmer, M Snape… - Journal of Neurology …, 1999 - jnnp.bmj.com
Alzheimer's disease is one of the most common causes of mental deterioration in elderly
people, accounting for around 50%-60% of the overall cases of dementia among persons …

An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer's disease

A Haake, K Nguyen, L Friedman… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is the most common cause of major neurocognitive
disorders with a prevalence in the US of about 5.7 million in 2018. With the disease burden …

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease

M Sano, C Ernesto, RG Thomas… - … England Journal of …, 1997 - Mass Medical Soc
Background There is evidence that medications or vitamins that increase the levels of brain
catecholamines and protect against oxidative damage may reduce the neuronal damage …

Polymorphism of human cytochrome P450 enzymes and its clinical impact

SF Zhou, JP Liu, B Chowbay - Drug metabolism reviews, 2009 - Taylor & Francis
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease

SL Rogers, MR Farlow, RS Doody, R Mohs… - Neurology, 1998 - AAN Enterprises
The efficacy and safety of donepezil as a treatment for patients with mild to moderate
Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients …

Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease

PB Watkins, HJ Zimmerman, MJ Knapp, SI Gracon… - Jama, 1994 - jamanetwork.com
Objective.—To characterize the hepatic effects of tacrine treatment in patients with
Alzheimer's disease. Design.—Controlled trials of tacrine therapy consisting of two blinded …

Therapeutic applications of compounds in the Magnolia family

YJ Lee, YM Lee, CK Lee, JK Jung, SB Han… - Pharmacology & …, 2011 - Elsevier
The bark and/or seed cones of the Magnolia tree have been used in traditional herbal
medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4 …