The oxytocin receptor signalling system and breast cancer: a critical review

H Liu, CW Gruber, PF Alewood, A Möller… - Oncogene, 2020 - nature.com
Breast cancer is making up one-quarter of all new female cancer cases diagnosed
worldwide. Breast cancer surgeries, radiation therapies, cytotoxic chemotherapies and …

Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity

P Wang, HP Yang, S Tian, L Wang, SC Wang… - Journal of …, 2015 - Elsevier
Interactions between the nervous system and immune system have been studied
extensively. However, the mechanisms underlying the neural regulation of immune activity …

Mitochondrial targeted peptides for cancer therapy

S Farsinejad, Z Gheisary, S Ebrahimi Samani… - Tumor Biology, 2015 - Springer
Mitochondria are a key pharmacological target in all cancer cells, since the structure and
function of this organelle is different between healthy and malignant cells. Oxidative …

[HTML][HTML] Oxytocin and cancer: An emerging link

B Lerman, T Harricharran… - World journal of clinical …, 2018 - ncbi.nlm.nih.gov
The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is
involved in a number of physiological processes. Understanding of its effects is gradually …

Oxytocin mediates the beneficial effects of the exercise training on breast cancer

AM Alizadeh, Z Heydari, M Rahimi… - Experimental …, 2018 - Wiley Online Library
New Findings What is the central question of this study? We hypothesized that potential anti‐
tumour effects of exercise training might be mediated by oxytocin and explored the …

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer

H Liu, M Muttenthaler - Biomedicines, 2022 - mdpi.com
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited
treatment options and high mortality. The oxytocin receptor (OTR) is a class-A G protein …

[HTML][HTML] The function of oxytocin: a potential biomarker for prostate cancer diagnosis and promoter of prostate cancer

H Xu, S Fu, Q Chen, M Gu, J Zhou, C Liu, Y Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Purpose To measure the level of oxytocin in serum and prostate cancer (PCa) tissue and
study its effect on the proliferation of PCa cells. Results Oxytocin level in serum was …

Attenuation of oxytocin and serotonin 2A receptor signaling through novel heteroreceptor formation

B Chruscicka, SE Wallace Fitzsimons… - ACS Chemical …, 2019 - ACS Publications
The oxytocin receptor (OTR) and the 5-hydroxytryptamine 2A receptor (5-HTR2A) are
expressed in similar brain regions modulating central pathways critical for social and …

[HTML][HTML] Effect of a high-intensity interval training on serum microRNA levels in women with breast cancer undergoing hormone therapy. A single-blind randomized …

S Alizadeh, A Isanejad, S Sadighi, S Khalighfard… - Annals of physical and …, 2019 - Elsevier
Background The role of microRNAs (miRs) in hormone therapy (HT) is of keen interest in
developing biomarkers and treatments for individuals with breast cancer. Although miRs are …

Oxytocin effects on the inhibition of the NF-κB/miR195 pathway in mice breast cancer

V Khori, AM Alizadeh, S Khalighfard, Y Heidarian… - Peptides, 2018 - Elsevier
Highlights•Oxytocin can decrease the volume and weight of tumors in mice breast
cancer.•Oxytocin administration can increase the mRNA expressionsof miR-195, OTR, and …