Biological metals and metal-targeting compounds in major neurodegenerative diseases
KJ Barnham, AI Bush - Chemical Society Reviews, 2014 - pubs.rsc.org
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
I Benilova, E Karran, B De Strooper - Nature neuroscience, 2012 - nature.com
The'toxic Aβ oligomer'hypothesis has attracted considerable attention among Alzheimer's
disease researchers as a way of resolving the lack of correlation between deposited amyloid …
disease researchers as a way of resolving the lack of correlation between deposited amyloid …
Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study: progress and observations from 2,359 older adults spanning the spectrum from …
C Fowler, SR Rainey-Smith, S Bird… - Journal of …, 2021 - journals.sagepub.com
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …
Brain amyloid-β oligomers in ageing and Alzheimer's disease
Alzheimer's disease begins about two decades before the onset of symptoms or neuron
death, and is believed to be caused by pathogenic amyloid-β aggregates that initiate a …
death, and is believed to be caused by pathogenic amyloid-β aggregates that initiate a …
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
CL Masters, DJ Selkoe - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …
The role of metallobiology and amyloid‐β peptides in Alzheimer's disease
J. Neurochem.(2012) 120 (Suppl. 1), 149–166. Abstract The biggest risk factor for
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …
2014 Update of the Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2015 - Elsevier
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing,
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …
[HTML][HTML] Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes
Soluble Aβ oligomers contribute importantly to synaptotoxicity in Alzheimer's disease, but
their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were …
their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were …
Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is
growing along with the increased life expectancy. Although the accumulation and deposition …
growing along with the increased life expectancy. Although the accumulation and deposition …
Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain
The primary structure of canonical amyloid-β-protein was elucidated more than 30 years
ago, yet the forms of amyloid-β that play a role in Alzheimer's disease pathogenesis remain …
ago, yet the forms of amyloid-β that play a role in Alzheimer's disease pathogenesis remain …