Regulatory role of short-chain fatty acids in inflammatory bowel disease

Z Zhang, H Zhang, T Chen, L Shi, D Wang… - Cell Communication and …, 2022 - Springer
Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of
the gastrointestinal tract. Accumulating evidence shows that the development of IBD is …

[HTML][HTML] Role of short chain fatty acids in gut health and possible therapeutic approaches in inflammatory bowel diseases

MAF Caetano, P Castelucci - World Journal of Clinical Cases, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBDs) are characterized by inflammation in the
gastrointestinal tract and include Ulcerative Colitis and Crohn's Disease. These diseases …

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

J Zhang, YJ Huang, JY Yoon, J Kemmitt, C Wright… - Med, 2021 - cell.com
Background The gut microbiome plays an important role in human health and disease.
Gnotobiotic animal and in vitro cell-based models provide some informative insights into …

A gut butyrate‑producing bacterium Butyricicoccus pullicaecorum regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2 …

SC Chang, MH Shen, CY Liu, CM Pu… - Oncology …, 2020 - spandidos-publications.com
Gut microbes influence tumor development and progression in the intestines and may
provide a novel paradigm for the treatment of colorectal cancer (CRC). Gut dysbiosis may be …

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal …

CC Chang, WY Kao, CY Liu… - International …, 2022 - spandidos-publications.com
The chromosome segregation 1‑like (CSE1L) protein, which regulates cellular mitosis and
apoptosis, was previously found to be overexpressed in colorectal cancer (CRC) cells …

Butyrate ameliorates mitochondrial respiratory capacity of the motor-neuron-like cell line NSC34-G93A, a cellular model for ALS

X Li, L Dong, A Li, J Yi, M Brotto, J Zhou - Biomolecules, 2022 - mdpi.com
Mitochondrial defects in motor neurons are pathological hallmarks of ALS, a neuromuscular
disease with no effective treatment. Studies have shown that butyrate, a natural gut-bacteria …

Sodium butyrate combined with docetaxel for the treatment of lung adenocarcinoma A549 cells by targeting Gli1

M Chen, W Jiang, C Xiao, W Yang, Q Qin… - OncoTargets and …, 2020 - Taylor & Francis
Purpose This study is aimed to investigate the combined treating efficacy of sodium butyrate
and docetaxel on proliferation and apoptosis of the lung adenocarcinoma A549 cell line …

Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

S Facchin, L Bertin, E Bonazzi, G Lorenzon… - Life, 2024 - mdpi.com
The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as
the gut microbiota, which play a pivotal role in breaking down undigested foods, such as …

Butyrate protects myenteric neurons loss in mice following experimental ulcerative colitis

MAF Caetano, HIR Magalhães, JRL Duarte… - Cells, 2023 - mdpi.com
The enteric nervous system is affected by inflammatory bowel diseases (IBD). Gut microbiota
ferments dietary fibers and produces short-chain fatty acids, such as Butyrate, which bind to …

Dietary Flaxseed and Flaxseed Oil Differentially Modulate Aspects of the Microbiota Gut–Brain Axis Following an Acute Lipopolysaccharide Challenge in Male C57Bl …

DBH Livingston, A Sweet, A Rodrigue, L Kishore… - Nutrients, 2023 - mdpi.com
The microbiota gut–brain axis (mGBA) is an important contributor to mental health and
neurological and mood disorders. Lipopolysaccharides (LPS) are endotoxins that are …