Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
The T-cell response to HIV
B Walker, A McMichael - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID
CB Jabara, CD Jones, J Roach… - Proceedings of the …, 2011 - National Acad Sciences
Viruses can create complex genetic populations within a host, and deep sequencing
technologies allow extensive sampling of these populations. Limitations of these …
technologies allow extensive sampling of these populations. Limitations of these …
Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I
SR Starck, V Jiang, M Pavon-Eternod, S Prasad… - Science, 2012 - science.org
Effective immune surveillance by cytotoxic T cells requires newly synthesized polypeptides
for presentation by major histocompatibility complex (MHC) class I molecules. These …
for presentation by major histocompatibility complex (MHC) class I molecules. These …
Definition of the viral targets of protective HIV-1-specific T cell responses
Background The efficacy of the CTL component of a future HIV-1 vaccine will depend on the
induction of responses with the most potent antiviral activity and broad HLA class I …
induction of responses with the most potent antiviral activity and broad HLA class I …
The human leukocyte antigen–presented ligandome of B lymphocytes
C Hassan, MGD Kester, AH de Ru, P Hombrink… - Molecular & Cellular …, 2013 - ASBMB
Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a
crucial role in adaptive immunology, mediating the communication between T cells and …
crucial role in adaptive immunology, mediating the communication between T cells and …
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control
Virus-specific cytotoxic T lymphocytes (CTL) with high levels of functional avidity have been
associated with viral clearance in hepatitis C virus infection and with enhanced antiviral …
associated with viral clearance in hepatitis C virus infection and with enhanced antiviral …
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …
Perception of self: distinguishing autoimmunity from autoinflammation
TS Van Kempen, MH Wenink, EFA Leijten… - Nature Reviews …, 2015 - nature.com
Rheumatic diseases can be divided in two groups, autoinflammatory and autoimmune
disorders. The clinical presentation of both types of diseases overlap, but the pathological …
disorders. The clinical presentation of both types of diseases overlap, but the pathological …
HIV-1 adaptation to HLA: a window into virus–host immune interactions
HIV-1 develops specific mutations within its genome that allow it to escape detection by
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …