A number of mechanisms ensure that the intestine is protected from pathogens and also
against our own intestinal microbiota. The outermost of these is the secreted mucus, which …

The airways mucus gel performs a critical function in defending the respiratory tract against
pathogenic and environmental challenges. In normal physiology, the secreted mucins, in …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Mucins are large glycoproteins that are ubiquitous in the animal kingdom. Mucins coat the
surfaces of many cell types and can be secreted to form mucus gels that assume important …

Trefoil factor (TFF) peptides, with a 40-amino acid motif and including six conserved cysteine
residues that form intramolecular disulfide bonds, are a family of mucin-associated secretory …

The detection of acute kidney injury (AKI) and the monitoring of chronic kidney disease
(CKD) is becoming more important in industrialized countries. Because of the direct relation …

Trefoil factor family peptides (TFF1, TFF2, TFF3) are typically co-secreted together with
mucins. Tff1 represents a gastric tumor suppressor gene in mice. TFFs are also synthesized …

The pathogenesis of inflammatory bowel diseases (IBDs) seems to involve a primary defect
in one or more of the elements responsible for the maintenance of intestinal homeostasis …