Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule
labeling and detecting. Of all the bioorthogonal reactions that have been developed, the …

Dinuclear alkynylcopper (I) ladderane complexes are prepared by a robust and simple
protocol involving the reduction of Cu2 (OH) 3OAc or Cu (OAc) 2 by easily oxidised alcohols …

CD13 receptor as a tumor vasculature biomarker has attracted great attention in cancer
research. Through phage display screening, NGR-containing peptides have been …

The clinical evaluation of stabilized tetrameric hemoglobin as alternatives to red cells
revealed that the materials caused significant increases in blood pressure and related …

Chemical cross-linking of human adult hemoglobin (Hb) prevents dissociation of the
tetrameric (αβ) 2 protein into its constituent non-functional αβ dimers when present outside …

Synthesis of novel host-guest functionalized polymers is presented along with structural
characterization using small-angle X-ray scattering (SAXS) of the resulting nanoparticles …

A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding
epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed …

While cross-linked hemoglobin tetramers are functional acellular oxygen carriers, their
ability to scavenge endogenous nitric oxide (NO) by endothelial pore penetration results in …

BACKGROUND Hemoglobin‐based oxygen carriers (HBOCs) are potential alternatives to
red blood cells in transfusions. Clinical trials using early versions of HBOCs noted adverse …