Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Animal studies are now showing the exciting potential to achieve significant functional
recovery following central nervous system (CNS) injury by manipulating both the inefficient …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Anatomically incomplete spinal cord injuries are often followed by considerable functional
recovery in patients and animal models, largely because of processes of neuronal plasticity …

Somatosensory feedback from proprioceptive afferents (PAs) is essential for locomotor
recovery after spinal cord injury. To determine where or when proprioception is required for …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …

It has been suggested that long-term modifications of synaptic transmission constitute the
foundation of the processes by which information is stored in the central nervous system. A …

Brain cells are immersed in a complex structure forming the extracellular matrix. The
composition of the matrix gradually matures during postnatal development, as the brain …

Most studies targeting chronic spinal cord injury (SCI) have concluded that neural
stem/progenitor cell (NS/PC) transplantation exerts only a subclinical recovery; this in …