Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion

JY Han, Q Li, ZZ Ma, JY Fan - Pharmacology & therapeutics, 2017 - Elsevier
Microcirculation dysfunction and organ injury after ischemia and reperfusion (I/R) result from
a complex pathologic process consisting of multiple links, with metabolism impairment in the …

Focus on notoginsenoside R1 in metabolism and prevention against human diseases

H Liu, J Yang, W Yang, S Hu, Y Wu… - Drug Design …, 2020 - Taylor & Francis
Abstract Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax
notoginseng (PN) root, which is well known in the prescription for mediating the micro …

High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae

X Li, Y Wang, Z Fan, Y Wang, P Wang, X Yan… - Metabolic …, 2021 - Elsevier
Abstract The Chinese medicinal plant Panax notoginseng has been traditionally used to
activate blood flow and circulation, and to prevent blood stasis. P. notoginseng contains …

Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

B Sun, J Xiao, XB Sun, Y Wu - British journal of pharmacology, 2013 - Wiley Online Library
Background and Purpose Notoginsenoside R1 (NG‐R1), a novel phytoestrogen isolated
from P anax notoginseng, is believed to have anti‐inflammatory, anti‐oxidative and anti …

[HTML][HTML] Notoginsenoside R1 upregulates miR-221-3p expression to alleviate ox-LDL-induced apoptosis, inflammation, and oxidative stress by inhibiting the TLR4/NF …

L Zhu, X Gong, J Gong, Y Xuan, T Fu, S Ni… - Brazilian Journal of …, 2020 - SciELO Brasil
Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular
endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs …

ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury

K He, L Yan, CS Pan, YY Liu, YC Cui… - American Journal …, 2014 - journals.physiology.org
Cardiac ischemia-reperfusion (I/R) injury remains a challenge for clinicians, which initiates
with energy metabolism disorder. The present study was designed to investigate the …

Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats

WJ Liu, HT Tang, YT Jia, B Ma, JF Fu, Y Wang, KY Lv… - Shock, 2010 - journals.lww.com
Abstract Ischemia-reperfusion (I/R) injury of the kidney is a complex pathophysiological
process and a major cause of acute renal failure. It has been shown that I/R injury is related …

Notoginsenoside R1: A systematic review of its pharmacological properties

S Guo, X Xi, J Li - Die Pharmazie-An International Journal of …, 2019 - ingentaconnect.com
Notoginsenoside R1 is one of major bioactive compounds extracted from Panax
notoginseng (Burk.) dry roots and rhizomes of FH Chen, which has been increasingly used …

Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced …

M Lu, K Xie, X Lu, L Lu, Y Shi, Y Tang - Investigational New Drugs, 2021 - Springer
Tumor microenvironment is a critical participant in the initiation, progression and drug
resistance of carcinomas, including osteosarcoma. Notoginsenoside R1 (NGR1) is a …

Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/-mice

J Xiao, T Zhu, Y Yin, B Sun - European Journal of Pharmacology, 2018 - Elsevier
Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-
inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to …