Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

[HTML][HTML] Sarcopenic obesity: emerging mechanisms and therapeutic potential

CL Axelrod, WS Dantas, JP Kirwan - Metabolism, 2023 - Elsevier
Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: a new paradigm beyond sarcopenia

H Ahn, DW Kim, Y Ko, J Ha, YB Shin, J Lee… - Ageing Research …, 2021 - Elsevier
Myosteatosis, which is excessive fat infiltration in the skeletal muscle, is now considered a
distinct disease from sarcopenia. Advances in imaging technique have made muscle …

Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

H Alizadeh Pahlavani - Frontiers in endocrinology, 2022 - frontiersin.org
Sarcopenic obesity is defined as a multifactorial disease in aging with decreased body
muscle, decreased muscle strength, decreased independence, increased fat mass, due to …

Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes

RCR Meex, EE Blaak, LJC van Loon - Obesity Reviews, 2019 - Wiley Online Library
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Interplay of skeletal muscle and adipose tissue: sarcopenic obesity

MJ Park, KM Choi - Metabolism, 2023 - Elsevier
Sarcopenic obesity is becoming a global health concern, owing to the rising older
population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding …

Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis

X Gu, L Wang, S Liu, T Shan - Metabolism, 2023 - Elsevier
Skeletal muscle plays important roles in normal biological activities and whole-body energy
homeostasis in humans. The growth and development of skeletal muscle also directly …

Myosteatosis in cirrhosis: a review of diagnosis, pathophysiological mechanisms and potential interventions

M Ebadi, C Tsien, RA Bhanji, AR Dunichand-Hoedl… - Cells, 2022 - mdpi.com
Myosteatosis, or pathological excess fat accumulation in muscle, has been widely defined
as a lower mean skeletal muscle radiodensity on computed tomography (CT). It is reported …

Obesity as a premature aging phenotype—implications for sarcopenic obesity

E Nunan, CL Wright, OA Semola, M Subramanian… - Geroscience, 2022 - Springer
Obesity and aging have both seen dramatic increases in prevalence throughout society.
This review seeks to highlight common pathologies that present with obesity, along with the …

Inactivity and skeletal muscle metabolism: a vicious cycle in old age

E Rezuş, A Burlui, A Cardoneanu, C Rezuş… - International journal of …, 2020 - mdpi.com
Aging is an inevitable and gradually progressive process affecting all organs and systems.
The musculoskeletal system makes no exception, elderly exhibit an increased risk of …