In principle, proton therapy offers a substantial clinical advantage over conventional photon
therapy. This is because of the unique depth-dose characteristics of protons, which can be …

The original rationale for proton therapy was its highly conformal depth‐dose distributions
compared to photons, which allow greater sparing of normal tissues and escalation of tumor …

Motion and uncertainty in radiotherapy is traditionally handled via margins. The clinical
target volume (CTV) is expanded to a larger planning target volume (PTV), which is …

Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT,
represents the latest advanced PT technology for treating cancers, including thoracic …

The emergence of artificial general intelligence (AGI) is transforming radiation oncology. As
prominent vanguards of AGI, large language models (LLMs) such as GPT-4 and PaLM 2 can …

In this study, we evaluate the performance of the Segment Anything Model (SAM) model in
clinical radiotherapy. We collected real clinical cases from four regions at the Mayo Clinic …

Abstract Background Deformable Image Registration (DIR) is an essential technique
required in many applications of radiation oncology. However, conventional DIR …

In this review article, we review the 3 important aspects of linear-energy-transfer (LET) in
intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management …

Purpose The purpose of this study was to compare the impact of uncertainties and interplay
on 3-dimensional (3D) and 4D robustly optimized intensity modulated proton therapy (IMPT) …

Purpose Patient-specific ridge filters provide a passive means to modulate proton energy to
obtain a conformal dose. Here we describe a new framework for optimization of filter design …