Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely
understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid …

We gathered available RNA-seq and ChIP-seq data in a single database to better
characterize the target genes of thyroid hormone receptors in several cell types. This …

Thyroid hormones (THs) are important regulators of systemic energy metabolism. In the liver,
they stimulate lipid and cholesterol turnover and increase systemic energy bioavailability. It …

The energy homeostasis of the organism is orchestrated by a complex interplay of energy
substrate shuttling, breakdown, storage, and distribution. Many of these processes are …

Abstract Thyroid hormone (3, 5, 3'-triiodothyronine, T3) is a key regulator of pituitary gland
function. The response to T3 is thought to hinge crucially on interactions of nuclear T3 …

The proper organized expression of specific genes in time and space is responsible for the
organogenesis of the central nervous system including the cerebellum. The epigenetic …

Thyroid hormones (THs) are key hormones that regulate development and metabolism in
mammals. In man, the major target tissues for TH action are the brain, liver, muscle, heart …

Background: Thyroid hormone (TH) has actions in every tissue of the body and is essential
for normal development, as well as having important actions in the adult. The earliest …