Antivirals and vaccines for Enterovirus A71

JY Lin, YA Kung, SR Shih - Journal of biomedical science, 2019 - Springer
Abstract Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children
under five years old. EV-A71 infection in infants or young children can cause hand-foot-and …

Molecular pathogenicity of enteroviruses causing neurological disease

A Majer, A McGreevy, TF Booth - Frontiers in microbiology, 2020 - frontiersin.org
Enteroviruses are single-stranded positive-sense RNA viruses that primarily cause self-
limiting gastrointestinal or respiratory illness. In some cases, these viruses can invade the …

Role of non-coding RNA in neurological complications associated with enterovirus 71

F Yang, N Zhang, Y Chen, J Yin, M Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth
disease (HFMD). Studies have reported that EV71-induced infections including aseptic …

Delivery of miRNAs Using Porous Silicon Nanoparticles Incorporated into 3D Hydrogels Enhances MSC Osteogenesis by Modulation of Fatty Acid Signaling and …

S Shrestha, T Tieu, M Wojnilowicz… - Advanced …, 2024 - Wiley Online Library
Strategies incorporating mesenchymal stromal cells (MSC), hydrogels and osteoinductive
signals offer promise for bone repair. Osteoinductive signals such as growth factors face …

Therapeutic targets for enterovirus infections

M Laajala, D Reshamwala… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Enteroviruses are among the most common viruses causing a huge number of
acute and chronic infections leading to high economic costs. Novel nontoxic antivirals that …

Technology of RNA interference in advanced medicine

F Abedini, M Ebrahimi, H Hosseinkhani - MicroRNA, 2018 - ingentaconnect.com
Background: RNA interference (RNAi) and related pathways involving small interfering
RNAs (siRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs) regulate …

miRNAs in enterovirus infection

I Engelmann, EK Alidjinou, A Bertin… - Critical reviews in …, 2018 - Taylor & Francis
During the last years, it has become evident that miRNAs are important players in almost all
physiological and pathological processes, including viral infections. Enterovirus infections …

Host transcriptomic response following administration of rotavirus vaccine in infants' mimics wild type infection

A Gómez-Carballa, R Barral-Arca… - Frontiers in …, 2021 - frontiersin.org
Background Rotavirus (RV) is an enteric pathogen that has devastating impact on childhood
morbidity and mortality worldwide. The immunologic mechanism underlying the protection …

Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma

MB Khan, R Ruggieri, E Jamil, NL Tran, C Gonzalez… - Molecular …, 2021 - Springer
Background Glioblastoma is the most common primary brain tumor and remains uniformly
fatal, highlighting the dire need for developing effective therapeutics. Significant intra-and …

In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases

R Chauhan, D Datzkiw, S Varma Shrivastav… - Plos one, 2018 - journals.plos.org
Protein myristoylation is a key protein modification carried out by N-Myristoyltransferase
(NMT) after Methionine aminopeptidase 2 (MetAP2) removes methionine from the amino …