ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

New developments in the production of theranostic pairs of radionuclides

SM Qaim, B Scholten, B Neumaier - Journal of Radioanalytical and …, 2018 - Springer
A brief historical background of the development of the theranostic approach in nuclear
medicine is given and seven theranostic pairs of radionuclides, namely 44g Sc/47 Sc, 64 …

An overview of PET radiochemistry, part 2: Radiometals

M Brandt, J Cardinale, ML Aulsebrook… - Journal of Nuclear …, 2018 - Soc Nuclear Med
This continuing educational review provides an overview on radiometals used for PET.
General aspects of radiometal-based radiotracers are covered, and the most frequently …

[HTML][HTML] Clinical translation and first in-human use of [44Sc] Sc-PSMA-617 for PET imaging of metastasized castrate-resistant prostate cancer

E Eppard, A de la Fuente, M Benešová, A Khawar… - Theranostics, 2017 - ncbi.nlm.nih.gov
Background: Various trivalent radiometals are well suited for labeling of DOTA-conjugated
variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The …

Production of novel diagnostic radionuclides in small medical cyclotrons

MA Synowiecki, LR Perk, JFW Nijsen - EJNMMI radiopharmacy and …, 2018 - Springer
The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its
industrial potential is composed of small medical cyclotrons with a proton energy below 20 …

Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements

R Mikolajczak, S Huclier-Markai, C Alliot… - EJNMMI …, 2021 - Springer
In the frame of “precision medicine”, the scandium radionuclides have recently received
considerable interest, providing personalised adjustment of radiation characteristics to …

Re‐thinking the role of radiometal isotopes: Towards a future concept for theranostic radiopharmaceuticals

J Notni, HJ Wester - Journal of Labelled Compounds and …, 2018 - Wiley Online Library
The potential and future role of certain metal radionuclides, for example, 44Sc, 89Zr, 86Y,
64Cu, 68Ga, 177Lu, 225Ac, and 213Bi, and several terbium isotopes has been …

Current advances in ligand design for inorganic positron emission tomography tracers 68 Ga, 64 Cu, 89 Zr and 44 Sc

TW Price, J Greenman, GJ Stasiuk - Dalton transactions, 2016 - pubs.rsc.org
A key part of the development of metal based Positron Emission Tomography probes is the
chelation of the radiometal. In this review the recent developments in the chelation of four …

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb

Z Talip, C Favaretto, S Geistlich, NP Meulen - Molecules, 2020 - mdpi.com
The production of novel radionuclides is the first step towards the development of new
effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and …