Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cognition. While the brain RAS has been studied before in the context of …

In the present study, we discuss the recent developments in oxysterol research. Exciting
results have been reported relating to the involvement of oxysterols in the fields of …

In Alzheimer's disease (AD), both cholesterol and glucose dysmetabolism precede the onset
of memory deficit and contribute to the disease's progression. It is indeed now believed that …

Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

Abstract The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-
hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid …

Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was
demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …