The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …

Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes
and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and …

Creatine is physiologically provided equally by diet and by endogenous synthesis from
arginine and glycine with successive involvements of arginine glycine amidinotransferase …

Precise coupling of spatially separated intracellular ATP-producing and ATP-consuming
processes is fundamental to the bioenergetics of living organisms, ensuring a fail-safe …

For many years, oxidative thiol modifications in cytosolic proteins were largely disregarded
as in vitro artifacts, and considered unlikely to play significant roles within the reducing …

Intensive activity of muscles causes a decline in performance, known as fatigue, that is
thought to be caused by the effects of metabolic changes on either the contractile machinery …

Huntington's disease (HD) is a progressive neurodegenerative illness for which there is no
effective therapy. We examined whether creatine, which may exert neuroprotective effects by …

The gene defect in Huntington's disease (HD) may result in an impairment of energy
metabolism. Malonate and 3-nitropropionic acid (3-NP) are inhibitors of succinate …