More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels

L Chen, B König, T Liu, S Pervaiz, YS Razzaque… - Biological …, 2019 - degruyter.com
The volume-regulated anion channel (VRAC) is a key player in the volume regulation of
vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and …

The volume-regulated anion channel is formed by LRRC8 heteromers–molecular identification and roles in membrane transport and physiology

T Stauber - Biological Chemistry, 2015 - degruyter.com
Cellular volume regulation is fundamental for numerous physiological processes. The
volume-regulated anion channel, VRAC, plays a crucial role in regulatory volume decrease …

[HTML][HTML] Exploration of the platelet proteome in patients with early-stage cancer

S Sabrkhany, MJE Kuijpers, JC Knol… - Journal of …, 2018 - Elsevier
Platelets play an important role in tumor growth and, at the same time, platelet
characteristics are affected by cancer presence. Therefore, we investigated whether the …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes

Y Liu, I Hoskins, M Geng, Q Zhao, J Chacko, K Qi… - …, 2024 - pmc.ncbi.nlm.nih.gov
Characterization of shared patterns of RNA expression between genes across conditions
has led to the discovery of regulatory networks and novel biological functions. However, it is …

The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

HI Jang, P Stevens, T Gao, E Galperin - The FEBS journal, 2021 - Wiley Online Library
Leucine‐rich repeat‐containing proteins (LRR proteins) are involved in supporting a large
number of cellular functions. In this review, we summarize recent advancements in …

[HTML][HTML] Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with …

SP McGovern, DC Purfield, SC Ring, TR Carthy… - Journal of dairy …, 2019 - Elsevier
Infection of cattle with bovine paratuberculosis (ie, Johne's disease) is caused by
Mycobacterium avium ssp. paratuberculosis (MAP) and results in a chronic incurable …

[HTML][HTML] Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer

G Mazzoccoli, T Colangelo, A Panza, R Rubino… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Altered functioning of the biological clock is involved in cancer onset and progression.
MicroRNAs (miRNAs) interact with the clock genes modulating the function of genetically …

miR‐218 contributes to drug resistance in multiple myeloma via targeting LRRC28

H Chen, W Cao, J Chen, D Liu, L Zhou… - Journal of Cellular …, 2021 - Wiley Online Library
Multiple myeloma (MM) is a malignant neoplasm featured by obvious drug resistance and
poor prognosis. MicroRNAs (miRNAs) are a class of small noncoding RNAs with crucial …