Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

The incidence of chronic pain is estimated to be 20–25% worldwide. Few patients with
chronic pain obtain complete relief from the drugs that are currently available, and more than …

Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

Common cancers, including cancers of the breast, lung, and prostate, frequently metastasize
to multiple bones where they can cause significant and life-altering pain. Similar to cancer …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

Primary afferent “pain” fibers (nociceptors) are divided into subclasses based on distinct
molecular and anatomical features, and these classes mediate noxious modality-specific …

There is both a nociceptive and neuropathic component of bone cancer pain. In bone cancer
pain, there is frequently a continual afferent drive of sensory nerve fibers that induces a …