The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …

methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …

Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in
the formation of multiple membrane-less organelles involved in RNA metabolism, including …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and
may, in principle, occur at many different levels. The leucine‐rich pentatricopeptide repeat …

The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies
including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic potential of …

Mutations in LRPPRC are responsible for the French Canadian variant of Leigh syndrome
(LSFC), a neurodegenerative disorder caused by a tissue-specific deficiency in cytochrome …

In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast
and DDX3 from human form a well-defined subfamily that is characterized by high sequence …