Functional bacterial amyloids: understanding fibrillation, regulating biofilm fibril formation and organizing surface assemblies

TV Sønderby, Z Najarzadeh, DE Otzen - Molecules, 2022 - mdpi.com
Functional amyloid is produced by many organisms but is particularly well understood in
bacteria, where proteins such as CsgA (E. coli) and FapC (Pseudomonas) are assembled as …

Inhibitory activities of grape bioactive compounds against enzymes linked with human diseases

V Dwibedi, S Jain, D Singhal, A Mittal, SK Rath… - Applied microbiology …, 2022 - Springer
A quest for identification of novel, safe and efficient natural compounds, as additives in the
modern food and cosmetic industries, has been prompted by concerns about toxicity and …

Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers

R Limbocker, R Staats, S Chia, FS Ruggeri… - Frontiers in …, 2021 - frontiersin.org
The aberrant aggregation of proteins is a key molecular event in the development and
progression of a wide range of neurodegenerative disorders. We have shown previously …

Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review

Z Sebghatollahi, M Ghanadian, P Agarwal… - ACS Food Science & …, 2022 - ACS Publications
Citrus fruits are one of the most popular sources of dietary flavonoids, such as hesperidin,
hesperetin, naringin, naringenin, quercetin, rutin, diosmin, diosmetin, kaempferol, myricetin …

[HTML][HTML] Chromolaena odorata (Siam weed): A natural reservoir of bioactive compounds with potent anti-fibrillogenic, antioxidative, and cytocompatible properties

FN Eze, TJ Jayeoye - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Protein fibrillation and oxidative damage are closely associated with the development of
many chronic diseases such as Alzheimer's disease, Parkinson's disease and transthyretin …

Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases

L Xiang, Y Wang, S Liu, B Liu, X Jin, X Cao - International Journal of …, 2023 - mdpi.com
Protein aggregation is one of the hallmarks of aging and aging-related diseases, especially
for the neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's …

Navigating α‐Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets

M Galkin, A Priss, Y Kyriukha… - The Chemical …, 2024 - Wiley Online Library
Parkinson's disease is a yet incurable, age‐related neurodegenerative disorder
characterized by the aggregation of small neuronal protein α‐synuclein into amyloid fibrils …

Polyphenols-based nanosheets of propolis modulate cytotoxic amyloid fibril assembly of α-synuclein

Y Rafiei, B Salmani, B Mirzaei-Behbahani… - ACS chemical …, 2022 - ACS Publications
Natural compounds with anti-aggregation capacity are increasingly recognized as viable
candidates against neurodegenerative diseases. Recently, the polyphenolic fraction of …

Natural Immunosuppressants as a Treatment for Chronic Insomnia Targeting the Inflammatory Response Induced by NLRP3/caspase-1/IL-1β Axis Activation: A …

Z Aghelan, S Pashaee, SH Abtahi, S Karima… - Journal of Neuroimmune …, 2023 - Springer
Chronic insomnia is an inflammatory-related disease with an important pathological basis
for various diseases which is a serious threat to a person's physical and mental health. So …

Systematic analysis of the molecular mechanisms mediated by coffee in Parkinson's disease based on network pharmacology approach

F Li, T Hatano, N Hattori - Journal of Functional Foods, 2021 - Elsevier
Many epidemiological studies have associated coffee consumption with a reduced
Parkinson's disease (PD) risk, but the molecular mechanisms remain unclear. In this study …