Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator

D Xhindoli, S Pacor, M Benincasa, M Scocchi… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

D Vandamme, B Landuyt, W Luyten, L Schoofs - Cellular immunology, 2012 - Elsevier
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …

Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Cathelicidins modulate TLR-activation and inflammation

MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

Membrane active peptides and their biophysical characterization

FG Avci, B Sariyar Akbulut, E Ozkirimli - Biomolecules, 2018 - mdpi.com
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Antimicrobial peptides: An overview of their structure, function and mechanism of action

R Zhang, L Xu, C Dong - Protein and Peptide Letters, 2022 - ingentaconnect.com
In recent years, the antibiotic resistance of pathogenic bacteria has become an increasing
public health threat. Finding alternatives to antibiotics may be an effective solution to the …

The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs

K Kuroda, K Okumura, H Isogai, E Isogai - Frontiers in oncology, 2015 - frontiersin.org
Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …