Abstract Several studies in Bioinformatics, Computational Biology and Systems Biology rely
on the definition of physico-chemical or mathematical models of biological systems at …

Embryonic epithelia achieve complex morphogenetic movements, including in-plane
reshaping, bending and folding, through the coordinated action and rearrangement of …

Wound healing in the pediatric patient is of utmost clinical and social importance because
hypertrophic scarring can have aesthetic and psychological sequelae, from early childhood …

We present a computational model to study the spatio-temporal dynamics of epidermis
homoeostasis under normal and pathological conditions. The model consists of a population …

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an
abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells …

Morphogenetic modelling and simulation help to understand the processes by which the
form and shapes of organs (organogenesis) and organisms (embryogenesis) emerge. This …

The epidermis and the stratum corneum (SC) as its outermost layer have evolved to protect
the body from evaporative water loss to the environment. To morphologically represent the …

The exact mechanism controlling cell growth remains a grand challenge in developmental
biology and regenerative medicine. The Drosophila wing disc tissue serves as an ideal …

During their lifetime, superorganisms, like unitary organisms, undergo transformations that
change the machinery of their collective behaviour. Here, we suggest that these …

In this paper, a new three-dimensional modelling approach is described for studying fluid–
viscoelastic cell interaction, the subcellular element Langevin (SCEL) method, with cells …