Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of
tumor cells and their spread to various organs and tissues of body, providing undesirable …

Among the different kinds of tumors threatening human life, lung cancer is one that is
commonly observed in both males and females. The aggressive behavior of lung cancer …

Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side
effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can …

Astragalin is a flavonoid found in a variety of natural plants. It has anti-inflammatory, anti-
oxidant effects and has inhibited effects against several malignant tumor cell types …

Abnormal glycosylation of cancer cells is considered a key factor of carcinogenesis related
to growth, proliferation, migration and invasion of tumor cells. Many plant-based …

Background Paeonol is the extractive of Paeonia suffruticosa Andr and is reported to reverse
the chemotherapy resistance of cancer cells. The present study explores the role of paeonol …

Cancer represents one of the leading causes of mortality worldwide. Conventional clinical
treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy …

Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia
suffruticosa that has been widely used in the clinical treatment of some inflammatory-related …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

The abnormal immune response mediated by malignant melanoma is related to PD1.
Paeonol has pharmacological antitumor activity. Previous studies have indicated that …