Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Two complementary approaches were used in search of the intracellular targets of the toxic
PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of …

This review on the role of neurofilaments as surrogate markers for axonal degeneration in
neurological diseases provides a brief background to protein synthesis, assembly, function …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …

Five major types of intermediate filament (IF) proteins are expressed in mature neurons: the
three neurofilament proteins (NF‐L, NF‐M, and NF‐H), α‐internexin, and peripherin. While …

In this review, we describe speculative ideas and early stage research concerning the flow
of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites …

α-Internexin, a neuronal intermediate filament protein implicated in neurodegenerative
disease, coexists with the neurofilament (NF) triplet proteins (NF-L, NF-M, and NF-H) but has …

Abundant abnormal aggregates of cytoskeletal proteins are neuropathological signatures of
many neurodegenerative diseases that are broadly classified by filamentous aggregates of …

Abstract Development of peripheral nervous system (PNS) myelin involves a coordinated
series of events between growing axons and the Schwann cell (SC) progenitors that will …