Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Cytomegalovirus and glioblastoma: a review of the biological associations and therapeutic strategies

T Yang, D Liu, S Fang, W Ma, Y Wang - Journal of clinical medicine, 2022 - mdpi.com
Glioblastoma is the most common and aggressive malignancy in the adult central nervous
system. Cytomegalovirus (CMV) plays a crucial role in the pathogenesis and treatment of …

EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes

R El Baba, S Pasquereau, S Haidar Ahmad, F Monnien… - Oncogene, 2023 - nature.com
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential …

Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes

J Guyon, S Haidar Ahmad, R El Baba… - Cancer Gene …, 2024 - nature.com
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in glioblastoma multiforme (GB). Herewith, we present the …

Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer

K Baby, S Maity, CH Mehta, UY Nayak, GG Shenoy… - Scientific Reports, 2023 - nature.com
Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and
the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt …

SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells

L Wen, XZ Wang, Y Qiu, YP Zhou, QY Zhang… - PLoS …, 2023 - journals.plos.org
The presence of human cytomegalovirus (HCMV) in glioblastoma (GBM) and improved
outcomes of GBM patients receiving therapies targeting the virus have implicated HCMV in …

Human cytomegalovirus infection enhances 5‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer

MR Pantalone, N Martin Almazan… - International …, 2023 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation
promotes CRC development, however, the underlying etiological factors are unknown …

Human Cytomegalovirus Protein Expression Is Correlated with Shorter Overall Survival in Breast Cancer Patients: A Cohort Study

J Touma, MR Pantalone, A Rahbar, Y Liu, K Vetvik… - Viruses, 2023 - mdpi.com
Background: Human cytomegalovirus (HCMV) is increasingly suggested to be involved in
human carcinogenesis and onco-modulation due to its ability to contribute to all hallmarks of …

Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas

A Kishk, M Pires Pacheco, T Heurtaux… - Briefings in …, 2024 - academic.oup.com
Gliomas are the most common type of malignant brain tumors, with glioblastoma multiforme
(GBM) having a median survival of 15 months due to drug resistance and relapse. The …

Focal-to-bilateral tonic-clonic seizures and High-grade CMV-infection are poor survival predictors in Tumor-related Epilepsy Adult-type diffuse gliomas—A single …

F Maria, MR Pantalone, CS Nauclér… - Heliyon, 2024 - cell.com
Introduction Previous studies have reported a correlation between a high-grade CMV-
infection and an unfavorable prognosis in glioblastoma (GB). Epilepsy has been associated …