Mood disorders and type 2 diabetes mellitus (T2DM) are prevalent conditions that often co-
occur. We reviewed the available evidence from longitudinal and Mendelian randomisation …

ABSTRACT Aim/Hypothesis Emerging evidence suggests that glucagon-like peptide-1
receptor agonists (GLP-1RAs) may exert positive effects in patients with depression. Our aim …

Accumulating evidence has suggested the important role of lifestyle factors in depressive
disorder. This paper aimed to introduce and outline recent research on epidemiological and …

Aims The objective of this umbrella review and meta‐analysis was to evaluate the effect of
diabetes on risk of dementia, as well as the mitigating effect of antidiabetic treatments …

Advances in psychopharmacology have been significantly slower to evolve than in other
disciplines of medicine and therefore investigation into novel therapeutic approaches is …

As an adjunct therapy, metformin enhances the efficacy of conventional antidepressant
medications. However, its mode of action remains unclear. Here, metformin was found to …

The role of altered brain mitochondrial regulation in psychiatric pathologies, including Major
Depressive Disorder (MDD), has attracted increasing attention. Aberrant mitochondrial …

This state-of-the-art review explores the relationship between depression and diabetes,
highlighting the two-way influences that make treatment challenging and worsen the …

Methods The study protocol is pre-registered with PROSPERO (CRD42023398184). We
systematically searched four databases, including PubMed, Cochrane, Web of Science, and …

Multiple factors associate diabetes with cognitive impairment and depression. Antidiabetic
drugs have reported antidepressant and pro-cognitive effects in diabetic and non-diabetic …