The recent successes of adoptive T-cell immunotherapy for the treatment of hematologic
malignancies have highlighted the need for manufacturing processes that are robust and …

We studied safety and proof of concept of a phase I/II trial with chimeric antigen receptor
(CAR) T-cells in patients with metastatic renal cell carcinoma (mRCC). The CAR was based …

Chimeric antigen receptor (CAR)-modified T cell therapy has the potential to improve the
overall survival of patients with malignancies by enhancing the effectiveness of CAR T cells …

Head and neck carcinoma (HNC) are diseases arising from several tracts of the
aerodigestive ways. Most HNC are squamous cell carcinoma (SCCHN). Immunotherapy is a …

The human immune system consists of a highly intelligent network of billions of
independent, self-organized cells that interact with each other. Machine learning (ML) is an …

The therapeutic efficacy of adoptive transfer of T cells transduced with chimeric antigen
receptors (CARs) has been limited in the treatment of solid cancers, partly due to tumor …

Leucocyte subpopulations in both lymphoid and myeloid lineages have a significant impact
on antitumor immune response. While radiation-induced lymphopenia is being studied …

Human hepatocellular carcinoma (HCC) is the third most common cause of cancer-related
death. Alpha-fetoprotein (AFP) is perhaps the best-defined tumor marker for HCC, and as …

Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike
well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of …

Memory T cells expressing stem cell–like properties have been described recently. The
capacity of self-renewal and differentiation into various memory/effector subsets make them …