Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …
factors, and can exhibit dramatic variation across geographically disparate populations of …
Integration of transcriptomic and proteomic approaches for snake venom profiling
CM Modahl, AJ Saviola… - Expert Review of …, 2021 - Taylor & Francis
Introduction Snake venoms contain many protein and peptide isoforms with high levels of
sequence variation, even within a single species. Areas covered In this review, we highlight …
sequence variation, even within a single species. Areas covered In this review, we highlight …
A review of rattlesnake venoms
Venom components are invaluable in biomedical research owing to their specificity and
potency. Many of these components exist in two genera of rattlesnakes, Crotalus and …
potency. Many of these components exist in two genera of rattlesnakes, Crotalus and …
The origin and diversification of a novel protein family in venomous snakes
The genetic origins of novelty are a central interest of evolutionary biology. Most new
proteins evolve from preexisting proteins but the evolutionary path from ancestral gene to …
proteins evolve from preexisting proteins but the evolutionary path from ancestral gene to …
The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom
MP Hogan, ML Holding, GS Nystrom… - Proceedings of the …, 2024 - National Acad Sciences
Developmental phenotypic changes can evolve under selection imposed by age-and size-
related ecological differences. Many of these changes occur through programmed …
related ecological differences. Many of these changes occur through programmed …
Evaluating the performance of de novo assembly methods for venom-gland transcriptomics
Venom-gland transcriptomics is a key tool in the study of the evolution, ecology, function,
and pharmacology of animal venoms. In particular, gene-expression variation and coding …
and pharmacology of animal venoms. In particular, gene-expression variation and coding …
Quantity, not quality: rapid adaptation in a polygenic trait proceeded exclusively through expression differentiation
MJ Margres, KP Wray, ATB Hassinger… - Molecular biology …, 2017 - academic.oup.com
A trait's genomic architecture can affect the rate and mechanism of adaptation, and although
many ecologically-important traits are polygenic, most studies connecting genotype …
many ecologically-important traits are polygenic, most studies connecting genotype …
Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from …
Abstract The Brown Treesnake (Boiga irregularis) is an arboreal, nocturnal, rear-fanged
venomous snake native to northern and eastern regions of Australia, Papua New Guinea …
venomous snake native to northern and eastern regions of Australia, Papua New Guinea …
Transcriptome-facilitated proteomic characterization of rear-fanged snake venoms reveal abundant metalloproteinases with enhanced activity
High-throughput technologies were used to identify venom gland toxin expression and to
characterize the venom proteomes of two rear-fanged snakes, Ahaetulla prasina (Asian …
characterize the venom proteomes of two rear-fanged snakes, Ahaetulla prasina (Asian …
Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression …
Abstract Changes in gene expression can rapidly influence adaptive traits in the early
stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins …
stages of lineage diversification. Venom is an adaptive trait comprised of numerous toxins …